By Nathan Morley
The Syrian Observatory for Human Rights – a monitoring group based in Britain – said the attack targeted a public gathering in Al Soussa, a small town not far from the border with Iraq.
Those killed were said to have been attending an event at an ice factory. Medical services were reportedly overwhelmed by the casualties.
It remains unclear if the plane used in the attack was American or from the Iraqi Air Force, but Iraqi jets have carried out several strikes against IS targets in Syria recently.
The American-led coalition is battling to eradicate the last small pockets of Islamic State activity in Syria and Iraq.
SANA, the official news agency of the Syrian government, reported the strike claimed 30 civilians were killed and blamed the US-led coalition of conducting the attack.